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E3 ligase Ligand 26

E3 Ligase Ligand

E3 Ligase Ligand 26 is a selective ligand for E3 ubiquitin ligases, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound plays a crucial role in the synthesis of the PROTAC SOS1 degrader, contributing to targeted protein degradation research. Its application extends to studies of cellular pathways and potential therapeutic interventions for various diseases through the modulation of protein levels.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	2911613-35-7
Applications	E3 Ligase Ligand
Formula	C₁₈H₁₁F₅N₂O₄
Molecular Weight	414.28
SMILES	O=C(NC1=O)CCN1C2=C(C)C=CC(C(OC3=C(F)C(F)=C(F)C(F)=C3F)=O)=C2

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.