E3 ligase Ligand 26

Catalog No.: A80591
E3 Ligase Ligand
E3 Ligase Ligand 26 is a selective ligand for E3 ubiquitin ligases, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound plays a crucial role in the synthesis of the PROTAC SOS1 degrader, contributing to targeted protein degradation research. Its application extends to studies of cellular pathways and potential therapeutic interventions for various diseases through the modulation of protein levels.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionE3 Ligase Ligand 26 is a selective ligand for E3 ubiquitin ligases, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound plays a crucial role in the synthesis of the PROTAC SOS1 degrader, contributing to targeted protein degradation research. Its application extends to studies of cellular pathways and potential therapeutic interventions for various diseases through the modulation of protein levels.
Product Information
Catalog NumA80591
FormulaC18H11F5N2O4
Molecular Weight414.28
CAS Number2911613-35-7
SMILESO=C(NC1=O)CCN1C2=C(C)C=CC(C(OC3=C(F)C(F)=C(F)C(F)=C3F)=O)=C2
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