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E3 ligase Ligand 46

E3 Ligase Ligand

E3 Ligase Ligand 46 is a potent ligand that targets E3 ligases, facilitating the development of targeted protein degradation strategies. It is specifically utilized in the synthesis of PROTAC SMARCA2/4 degrader-36, enabling the selective degradation of cellular proteins. This compound offers valuable insights into the role of E3 ligases in cellular signaling and protein homeostasis, making it essential for research in targeted therapeutics and protein regulation.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	3033591-48-6
Applications	E3 Ligase Ligand
Formula	C₂₂H₂₈N₆O₃S
Molecular Weight	456.56
SMILES	O[C@H](C[C@H]1C(N[C@H](C2=CC=C(C=C2)C3=C(N=CS3)C)C)=O)CN1C([C@H](C(C)C)N=[N+]=[N-])=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.