Fig. 1 · Structure
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E3 ligase Ligand 51
E3 Ligase Ligand
E3 Ligase Ligand 51 functions as a ligand for the E3 ligase CRBN, facilitating targeted protein degradation through the synthesis of PROTACs, specifically BTK Degrader-12. This compound plays a crucial role in the research of protein homeostasis, allowing for the selective degradation of target proteins. Its application is significant in the study of various diseases, including cancer, by modulating protein levels in cellular contexts.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Ligand / Binder |
| CAS Number | 2703915-71-1 |
| Applications | E3 Ligase Ligand |
| Formula | C16H19N3O3 |
| Molecular Weight | 301.34 |
| SMILES | O=CC1CCN(C2=CC=C(N(C(N3)=O)CCC3=O)C=C2)CC1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.