Fig. 1 · Structure
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E4177
Angiotensin II Receptor Antagonist
E4177 is an orally active angiotensin II receptor antagonist that plays a crucial role in the modulation of vascular responses. This compound effectively inhibits the proliferation of human aortic smooth muscle cells (HASMC) and contributes to alterations in cell surface area. Additionally, E4177 enhances the expression of platelet-derived growth factor (PDGF) receptor, making it a valuable tool for research into various vascular diseases and related therapeutic strategies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 135070-05-2 |
| Applications | Angiotensin II Receptor Antagonist |
| Formula | C24H21N3O2 |
| Molecular Weight | 383.44 |
| Synonyms | 57G709 |
| SMILES | O=C(C1=C(C2=CC=C(CN3C4=NC=CC(C)=C4N=C3C5CC5)C=C2)C=CC=C1)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.