Fig. 1 · Structure
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E67-2
H3K9 Jumonji Demethylase Inhibitor
E67-2 is a selective inhibitor of the KIAA1718 Jumonji domain, specifically targeting the H3K9 Jumonji demethylase with an IC50 value of 3.4 µM. It demonstrates low toxicity and effectively inhibits demethylation of histone H3 at lysine 9 (H3K9), as well as exhibiting activity against H3K4 demethylase. This compound is valuable for research focused on epigenetic regulation and the role of histone modifications in various biological processes.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1364914-62-4 |
| Applications | H3K9 Jumonji Demethylase Inhibitor |
| Formula | C21H36N6O2 |
| Molecular Weight | 404.55 |
| SMILES | CN(C)C1=C2C=C(OC)C(OCCCCCN)=CC2=NC(NCCCN(C)C)=N1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.