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EAPB0503

Antitumor Agents

EAPB0503 is a quinoline derivative that functions as an antitumor agent by exhibiting potent cytotoxicity against melanoma cells, with an IC50 of 200 nM. This compound induces specific cell cycle arrest in mitosis and directly triggers apoptosis in chronic myeloid leukemia (CML) cells, resulting in an increased G0 cell population, disruption of mitochondrial membrane potential, cleavage of PARP, and DNA fragmentation. Additionally, EAPB0503 effectively reduces BCR-ABL protein levels, highlighting its potential applications in cancer research and treatment.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	1140627-77-5
Applications	Antitumor Agents
Formula	C₁₈H₁₆N₄O
Molecular Weight	304.35
SMILES	COC1=CC(C2=CN=C3N2C4=C(C=CC=C4)N=C3NC)=CC=C1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.