Fig. 1 · Structure
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EB1
MNK Inhibitor
EB1 is a selective inhibitor of MNK kinases, exhibiting IC50 values of 0.69 μM for MNK1 and 9.4 μM for MNK2. This compound demonstrates significant anticancer activity by selectively inhibiting the growth of cancer cells while sparing normal cells. Additionally, EB1 promotes cell apoptosis and suppresses phosphorylation of eIF4E, making it a valuable tool for research in cancer biology and therapeutic development.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 42951-68-8 |
| Applications | MNK Inhibitor |
| Formula | C18H14N4 |
| Molecular Weight | 286.33 |
| SMILES | NC1=NNC2=C1C(C3=CC=CC=C3)=CC(C4=CC=CC=C4)=N2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.