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EBET-1593

BET Degrader

EBET-1593 is a selective BET PROTAC degrader that facilitates the ubiquitination and subsequent degradation of BET proteins. This compound serves as a lead payload for the synthesis of antibody-drug conjugates (ADCs), such as 84-EBET, which exhibits anti-tumor activity against pancreatic ductal adenocarcinoma. EBET-1593 is integral for research in targeted protein degradation and therapeutic strategies in oncology.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Degrader
CAS Number	3031540-97-0
Applications	BET Degrader
Formula	C₅₂H₅₇N₉O₆
Molecular Weight	904.07
SMILES	O=C1NC(CCN1C2=CC(C#CCNC3(CCN(C4CCN(CC4)C5=NC(C(C6=CC=CC=C6)(CO)OC7CC7)=C8C=C(C(C9=C(C%10=O)NC=C9)=CN%10C)C=CC8=N5)CC3)C)=CC=C2OC)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.