Fig. 1 · Structure
Documents & Downloads
EC359
LIFR Inhibitor
EC359 is a selective inhibitor of the leukemia inhibitory factor receptor (LIFR), exhibiting high affinity with a Kd of 10.2 nM. It effectively disrupts LIF/LIFR interactions, making it a valuable tool for research in oncology and stem cell biology. Additionally, EC359 features an alkyne moiety, which enables it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc), paving the way for various applications in click chemistry.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2012591-09-0 |
| Applications | LIFR Inhibitor |
| Formula | C36H38F2O2 |
| Molecular Weight | 540.68 |
| SMILES | C[C@@]12[C@](O)(C(F)(F)C#C)CC[C@@]1([H])[C@]3([H])CCC4=CC(CCC4=C3[C@@H](C5=CC=C(C6=C(C)C=C(C)C=C6C)C=C5)C2)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.