Fig. 1 · Structure
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Eeyarestatin I
ERAD Inhibitor
Eeyarestatin I is a potent inhibitor of endoplasmic reticulum-associated protein degradation (ERAD), specifically targeting the Sec61 translocon. By disrupting the p97-associated deubiquitinating process (PAD) and inhibiting atx3-dependent deubiquitination, Eeyarestatin I acts at a pre-proteasomal degradation stage. This compound is known to induce cell death through the activation of the pro-apoptotic protein NOXA, demonstrating its potential anticancer activity in various research applications focused on protein quality control and apoptosis.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 412960-54-4 |
| Applications | ERAD Inhibitor |
| Formula | C27H25Cl2N7O7 |
| Molecular Weight | 630.44 |
| SMILES | ON(C(C1(C)C)N(C(C=C2)=CC=C2Cl)C(N1CC(N/N=C/C=C/C(O3)=CC=C3[N+]([O-])=O)=O)=O)C(NC(C=C4)=CC=C4Cl)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.