Fig. 1 · Structure
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Eg5-IN-2
Eg5 Inhibitor
Eg5-IN-2 is a potent Eg5 inhibitor with an IC50 of less than 0.5 nM. It effectively disrupts the function of the Eg5 protein, which is essential for mitotic spindle formation and cell division. This compound can be utilized as an antibody-drug conjugate (ADC) payload, facilitating the development of targeted cancer therapies and advancing research in cell cycle regulation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1629735-05-2 |
| Applications | Eg5 Inhibitor |
| Formula | C31H38F3N5O3 |
| Molecular Weight | 585.66 |
| SMILES | CNC(CC([C@H](C1=NC(C2=CC(F)=CC=C2F)=CN1CC3=CC=CC=C3)N(C[C@H]4[C@H](CNC4)F)C([C@@H](O)C)=O)(C)C)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.