Fig. 1 · Structure
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EGFR/ErbB-2/ErbB-4 inhibitor-3
Tyrosine Kinase Inhibitor
EGFR/ErbB-2/ErbB-4 inhibitor-3 functions as a potent tyrosine kinase inhibitor, exhibiting IC50 values of 0.3 nM for ErbB1, 1.1 nM for ErbB2, and 0.5 nM for ErbB4. This compound serves as a valuable tool in cancer research, particularly in studies targeting EGFR-related signaling pathways. Additionally, it features an alkyne group, enabling its use in copper-catalyzed azide-alkyne cycloaddition (CuAAc), thus facilitating bioconjugation applications in chemical biology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 881001-19-0 |
| Applications | Tyrosine Kinase Inhibitor |
| Formula | C17H11ClFN5O |
| Molecular Weight | 355.75 |
| SMILES | O=C(C#CC)NC1=CC(C(NC(C=C2)=CC(Cl)=C2F)=NC=N3)=C3C=N1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.