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EGFR-IN-204

HER2 Exon 20 Mutation Inhibitor

EGFR-IN-204 is a HER2 exon 20 mutation inhibitor with selective action against wild-type EGFR. This compound demonstrates significant antiproliferative effects on cells that are reliant on the HER2 exon 20 YVMA insertion mutation, while exhibiting strong selectivity for wild-type HER2. EGFR-IN-204 is particularly relevant for research focusing on non-small cell lung cancer and the treatment of HER2-driven malignancies.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2989904-86-9
Applications	HER2 Exon 20 Mutation Inhibitor
Formula	C₃₁H₂₈FN₇O₃
Molecular Weight	565.60
SMILES	FC(C(C)=C(C=C1)OC2=CC3=NC=NN3C=C2)=C1NC4=NC=NC(C=C5)=C4C=C5O[C@@H]6C[C@H](CC7)N(C(C=C)=O)[C@H]7C6

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.