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EGFR Ligand-Linker Conjugates 1

Target Protein Ligand-Linker Conjugate

EGFR Ligand-Linker Conjugates 1 is a targeted protein ligand-linker conjugate designed to interact with the epidermal growth factor receptor (EGFR). This compound features a specific ligand for EGFR and a PROTAC linker that facilitates the recruitment of E3 ligases for targeted protein degradation. It is primarily utilized for the synthesis of PROTAC EGFR degrader 3, making it a valuable tool for studies in targeted therapy and protein degradation research.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	2768472-86-0
Applications	Target Protein Ligand-Linker Conjugate
Formula	C₃₇H₄₇N₉O₃
Molecular Weight	665.83
SMILES	C=CC(N1CCC[C@@H](C1)N2C3=C(N=C2NC4=CC=CC=C4)C=NC(NC5=CC=C(C=C5)N6CCN(CC6)CCCCCCCC(O)=O)=N3)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.