Fig. 1 · Structure
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EGIS-7625
5-HT2B Inhibtor
EGIS-7625 is a selective competitive inhibitor of the 5-HT2B receptor, exhibiting pKi values of 9.0 for 5-HT2B, and 6.2 and 7.7 for 5-HT2A and 5-HT2C, respectively. This compound has been shown to partially counteract m-chlorophenylpiperazine-induced hypomotility and hypophagia. EGIS-7625 is a valuable tool for investigating the role of 5-HT2B in various physiological and pathological processes, making it suitable for research in neuropharmacology and behavioral studies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 755040-97-2 |
| Applications | 5-HT2B Inhibtor |
| Formula | C18H24Cl2N4O2 |
| Molecular Weight | 399.31 |
| SMILES | NC1=CC(N2CCN(CC3=CC=CC=C3)CC2)=C([N+]([O-])=O)C=C1C.Cl.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.