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Fig. 1 · Structure
Cat. No.
A34571
CAS No.
2505078-08-8
Formula
C27H29FN10O
Mol. Weight
528.58

Documents & Downloads

Elenestinib

Tyrosine Kinase Inhibitor

Elenestinib is a selective orally active tyrosine kinase inhibitor, demonstrating a potent inhibitory effect on the KIT D816V mutant with an IC50 value of 6 nM. Its mechanism of action is primarily focused on inhibiting aberrant signaling pathways associated with systemic mastocytosis. Due to its limited ability to cross the blood-brain barrier, Elenestinib is particularly applicable in the investigation of hematologic disorders related to mast cell proliferation and activity.

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Specifications

Manufacturer Adooq Bioscience
Actions Inhibitor
CAS Number 2505078-08-8
Applications Tyrosine Kinase Inhibitor
Formula C27H29FN10O
Molecular Weight 528.58
Synonyms BLU-263
SMILES
OCCN1C=C(C=N1)C2=CN3N=CN=C(N4CCN(C5=NC=C([C@@](N)(C6=CC=C(C=C6)F)C)C=N5)CC4)C3=C2

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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