Fig. 1 · Structure
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Eleven-Nineteen-Leukemia Protein IN-3
ENL YEATS Domain Inhibitor
Eleven-Nineteen-Leukemia Protein IN-3 is a potent inhibitor of the ENL YEATS domain, exhibiting an IC50 value of 15.4 nM. This compound effectively down-regulates MYC expression in cellular models via ENL modulation. Additionally, Eleven-Nineteen-Leukemia Protein IN-3 has been shown to enhance the thermal stability of ENL protein in vitro, making it a valuable tool for research on chromatin-associated proteins and their roles in oncogenic pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2894121-83-4 |
| Applications | ENL YEATS Domain Inhibitor |
| Formula | C28H27N5O2 |
| Molecular Weight | 465.55 |
| SMILES | C[C@H]1CCCN1CC2=NC3=CC(NC(C4=CC=C5C(C6=CC=CC=C6C(N5C)=O)=C4)=O)=CC=C3N2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.