Fig. 1 · Structure
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ELOVL6-IN-5
ELOVL6 Inhibitor
ELOVL6-IN-5 is a selective inhibitor of the elongase enzyme of long-chain fatty acid family 6 (ELOVL6), exhibiting IC50 values of 85 nM for human and 38 nM for mouse ELOVL6. This compound demonstrates over 60-fold selectivity against other ELOVL family members (ELOVL1, 2, 3, 5) and has no significant impact on lipid synthesis enzymes such as ACC1 and ACC2. ELOVL6-IN-5 effectively alters hepatic fatty acid composition ratios in diet-induced obesity models, although it does not enhance insulin resistance. This compound is valuable for studies focused on metabolic diseases.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1135000-36-0 |
| Applications | ELOVL6 Inhibitor |
| Formula | C20H20F3N3O3S |
| Molecular Weight | 439.45 |
| SMILES | O=C(N1C2CCC1CC(S(=O)(C3=NC=CC=C3)=O)C2)NC4=CC=C(C(F)(F)F)C=C4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.