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Fig. 1 · Structure
Cat. No.
A17207
CAS No.
1642300-52-4
Formula
C17H10F6N6O
Mol. Weight
428.08

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Eltanexor

exportin-1 inhibitor

Eltanexor, also known as KPT-8602, is a second-generation exportin-1 inhibitor.

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Biological Activity

Cellular Effect

Cell Line Activity Value Description Reference
H9 IC50 139.4 nM Antiproliferative activity against human H9 cells assessed as inhibition of cell growth incubated for 4 hrs by CCK-8 assay [PMID: 35367710]
MM1.S IC50 64 nM Antiproliferative activity against human MM1.S cells assessed as inhibition of cell growth incubated for 4 hrs by CCK-8 assay [PMID: 35367710]
NAMALVA IC50 93.8 nM Antiproliferative activity against human NAMALVA cells assessed as inhibition of cell growth incubated for 4 hrs by CCK-8 assay [PMID: 35367710]
YT IC50 103.1 nM Antiproliferative activity against human YT cells assessed as inhibition of cell growth incubated for 4 hrs by CCK-8 assay [PMID: 35367710]

Specifications

Manufacturer Adooq Bioscience
Actions Inhibitor
CAS Number 1642300-52-4
Applications exportin-1 inhibitor
Formula C17H10F6N6O
Molecular Weight 428.08
Synonyms KPT-8602
SMILES
O=C(N)/C(C1=CN=CN=C1)=C/N2N=C(C3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)N=C2

Storage & Solubility

In Vitro Solubility

Reported Solubility

SolventReported Solubility
DMSO Warmed: 80 mg/mL (186.79 mM)
Water Insoluble
Ethanol Warmed: 1 mg/mL

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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