EMD 386088 free base

Catalog No.: A29647
5-HT6R Agonist
EMD 386088 free base is a potent agonist of the serotonin 6 receptor (5-HT6R). It has been shown to induce cell death and modulate ERK1/2 activity, making it a valuable tool in the study of neurodegenerative disorders. This reagent is particularly relevant for research applications related to Alzheimer's disease and schizophrenia, where 5-HT6R signaling plays a significant role.
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionEMD 386088 free base is a potent agonist of the serotonin 6 receptor (5-HT6R). It has been shown to induce cell death and modulate ERK1/2 activity, making it a valuable tool in the study of neurodegenerative disorders. This reagent is particularly relevant for research applications related to Alzheimer's disease and schizophrenia, where 5-HT6R signaling plays a significant role.
Product Information
Catalog NumA29647
FormulaC14H15ClN2
Molecular Weight246.74
CAS Number54635-62-0
SMILESCC(N1)=C(C2=CCNCC2)C3=C1C=CC(Cl)=C3
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