EMD386088 is a highly potent and selective agonist of the 5-HT6 receptor (5-HT6R) with an EC50 of 1.0 nM. This compound exhibits minimal activity against other serotonin receptors, displaying an IC50 of 34 nM primarily at the 5-HT3R. EMD386088 is known to modulate ERK1/2 activity, indicating its potential role in signaling pathways. This reagent is relevant for research applications related to Alzheimer's disease and schizophrenia, providing insight into neuropsychiatric disorders and their treatment.
EMD386088 is a highly potent and selective agonist of the 5-HT6 receptor (5-HT6R) with an EC50 of 1.0 nM. This compound exhibits minimal activity against other serotonin receptors, displaying an IC50 of 34 nM primarily at the 5-HT3R. EMD386088 is known to modulate ERK1/2 activity, indicating its potential role in signaling pathways. This reagent is relevant for research applications related to Alzheimer's disease and schizophrenia, providing insight into neuropsychiatric disorders and their treatment.
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