Fig. 1 · Structure
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EMD386088
5-HT6R Agonist
EMD386088 is a highly potent and selective agonist of the 5-HT6 receptor (5-HT6R) with an EC50 of 1.0 nM. This compound exhibits minimal activity against other serotonin receptors, displaying an IC50 of 34 nM primarily at the 5-HT3R. EMD386088 is known to modulate ERK1/2 activity, indicating its potential role in signaling pathways. This reagent is relevant for research applications related to Alzheimer's disease and schizophrenia, providing insight into neuropsychiatric disorders and their treatment.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 1171123-46-8 |
| Applications | 5-HT6R Agonist |
| Formula | C14H16Cl2N2 |
| Molecular Weight | 283.20 |
| SMILES | CC(N1)=C(C2=CCNCC2)C3=C1C=CC(Cl)=C3.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.