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$0.00 - CN Koyani, .et al. Empagliflozin Protects Heart From Inflammation and Energy Depletion via AMPK Activation, Pharmacol Res, 2020, May 17;158:104870 PMID: 32434052
Biological Activity
Empagliflozin is a potent, selective sodium glucose co-transporter-2 inhibitor that is in development for the treatment of type 2 diabetes.
Targets
| SGLT2 | SGLT5 | SGLT6 | SGLT1 | SGLT4 |
| 3.1 nM | 1.1 μM | 2 μM | 8.3 μM | 11 μM |
| In vitro (25°C) | DMSO | 88 mg/mL (195.15 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 15% Captisol | 14 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.18 mL | 110.89 mL | 221.77 mL |
| 0.5 mM | 4.44 mL | 22.18 mL | 44.35 mL |
| 1 mM | 2.22 mL | 11.09 mL | 22.18 mL |
| 5 mM | 0.44 mL | 2.22 mL | 4.44 mL |
*The above data is based on the productmolecular weight 450.91. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A12440 |
|---|---|
| CAS No. | 864070-44-0 |
| Formula | C23H27ClO7 |
| M. Wt | 450.91 |
| Purity | >98% |
| SMILES | C1COC[[email protected]]1OC2=CC=C(C=C2)CC3=C(C=CC(=C3)[[email protected]]4[[email protected]@H]([[email protected]]([[email protected]@H]([[email protected]](O4)CO)O)O)O)Cl |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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