Fig. 1 · Structure
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EN460
ERO1 Inhibitor
EN460 is a selective inhibitor of endoplasmic reticulum oxidation 1 (ERO1). With an IC50 value of 1.9 μM, EN460 shows a specific interaction with the reduced, active form of ERO1α, effectively preventing its reoxidation. This compound is instrumental for studies focused on oxidative stress, protein folding, and endoplasmic reticulum homeostasis in cellular models.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 496807-64-8 |
| Applications | ERO1 Inhibitor |
| Formula | C22H12ClF3N2O4 |
| Molecular Weight | 460.79 |
| SMILES | FC(F)(F)C1=NN(C2=CC(C(O)=O)=C(Cl)C=C2)C(/C1=C\C3=CC=C(C4=CC=CC=C4)O3)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.