Fig. 1 · Structure
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Enbezotinib
RET Inhibitor
Enbezotinib is a potent RET inhibitor that effectively hinders RET autophosphorylation. This compound demonstrates significant biological activity against various cancers driven by RET alterations. It is suitable for research applications focused on cancer biology and therapeutic targeting of RET-driven malignancies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2359649-81-1 |
| Applications | RET Inhibitor |
| Formula | C21H21FN6O3 |
| Molecular Weight | 424.43 |
| Synonyms | TPX-0046 |
| SMILES | FC(C=C1CN2C3=NC4=C5C=NN4C=C3O[C@]6([H])[C@@]2([H])CCC6)=CN=C1O[C@@H](C)CNC5=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.