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Form	MW
Encaleret sodium This page	536.01
Encaleret (JIT-305)	514.03

Encaleret sodium

CaSR Antagonist

Encaleret sodium is a potent antagonist of the calcium-sensing receptor (CaSR), demonstrating an IC50 of 12 nM. By inhibiting the excessive activity of gain-of-function CaSR variants, it effectively restores blood calcium levels, stimulates parathyroid hormone secretion, and enhances magnesium and phosphorus metabolism. This compound is valuable in research related to osteoporosis and autosomal dominant hypocalcemia type 1, providing insights into calcium homeostasis and its implications in bone health and mineral metabolism.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Antagonist
CAS Number	787584-62-7
Applications	CaSR Antagonist
Formula	C₂₉H₃₂ClFNNaO₄
Molecular Weight	536.01
Synonyms	CLTX-305 sodium; JTT-305 sodium; MK-5442 sodium
SMILES	FC(C=C1CC(C)(C)NC[C@@H](O)CO[C@@H](C2=C(C3=CC(C)=C(C=C3)C(O[Na])=O)C=CC=C2)C)=C(C=C1)Cl

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.