Enciprazine dihydrochloride is an orally active non-benzodiazepine anxiolytic that functions as a 5-HT1A receptor agonist and α1-adrenergic receptor antagonist. This compound demonstrates key biological activity by inducing electroencephalogram changes, characterized by a reduction in δ and θ wave power and an increase in α and fast β wave power. Enciprazine dihydrochloride exhibits anti-aggressive properties, alongside minimal sedative and ataxic effects. It also modulates plasma corticosterone levels and activates the hypothalamic-pituitary-adrenal axis, making it a valuable reagent for research into anxiety disorders, generalized anxiety syndrome, and psychosis.
Enciprazine dihydrochloride is an orally active non-benzodiazepine anxiolytic that functions as a 5-HT1A receptor agonist and α1-adrenergic receptor antagonist. This compound demonstrates key biological activity by inducing electroencephalogram changes, characterized by a reduction in δ and θ wave power and an increase in α and fast β wave power. Enciprazine dihydrochloride exhibits anti-aggressive properties, alongside minimal sedative and ataxic effects. It also modulates plasma corticosterone levels and activates the hypothalamic-pituitary-adrenal axis, making it a valuable reagent for research into anxiety disorders, generalized anxiety syndrome, and psychosis.
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