Fig. 1 · Structure
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Endosidin-2
EXO70 Inhibitor
Endosidin-2 is a selective inhibitor of the EXO70 subunit within the exocyst complex, interacting with its C-terminal domain to disrupt exocytosis and endosomal recycling. This compound induces abnormal accumulation of auxin transporters, such as PIN2, in the cytoplasm by promoting their degradation in the vacuole and alters Golgi morphology, resulting in atypical vesicular structures. Endosidin-2 is employed in research to investigate membrane trafficking dynamics, including vesicle sorting and polar growth in both plant and mammalian cells.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1839524-44-5 |
| Applications | EXO70 Inhibitor |
| Formula | C15H12FIN2O3 |
| Molecular Weight | 414.17 |
| Synonyms | ES2 |
| SMILES | O=C(N/N=C/C1=CC(OC)=C(O)C(I)=C1)C2=CC=CC(F)=C2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.