Fig. 1 · Structure
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Enfortumab vedotin-ejfv (solution)
Nectin-4 ADC
Enfortumab vedotin-ejfv (solution) is an antibody-drug conjugate (ADC) targeting Nectin-4, a critical adhesion protein implicated in tumorigenesis. This fully humanized IgG1 antibody is conjugated to the microtubule-disrupting agent MMAE via a protease-cleavable Val-Cit linker, allowing for precise delivery of the cytotoxic agent to cancer cells. Enfortumab vedotin-ejfv (solution) is primarily applied in research focused on the treatment of locally advanced or metastatic urothelial carcinoma, demonstrating significant biological activity in inhibiting tumor growth.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1346452-25-2 |
| Applications | Nectin-4 ADC |
| Molecular Weight | 152000 (average) |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.