ENMD-2076

Catalog No.: A10352
Aurora A / FLT3 Inhibitor
ENMD-2076 has selective activity against Aurora A and Flt3 with IC50 of 14 nM and 1.86 nM, 25-fold selective for Aurora A than over Aurora B and less potent to VEGFR2/KDR and VEGFR3, FGFR1 and FGFR2 and PDGFRα. Phase 2.
Grouped product items
Size Price Stock Qty
1mg
$35.00
In stock
2mg
$60.00
In stock
5mg
$75.00
In stock
10mg
$135.00
In stock
25mg
$285.00
In stock
50mg
$395.00
In stock
100mg
$645.00
In stock
10mM * 1mL in DMSO
$110.00
In stock
Bulk Size
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Important Notice: For research use only. We do not sell to patients.

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Biological Activity
Discription ENMD-2076 has selective activity against Aurora A and Flt3 with IC50 of 14 nM and 1.86 nM, 25-fold selective for Aurora A than over Aurora B and less potent to VEGFR2/KDR and VEGFR3, FGFR1 and FGFR2 and PDGFRα. Phase 2.
Targets
Target Value
Cell Research
Cell Line Type Value Description References
Product Information
Catalog Num A10352
Formula C21H25N7
Molecular Weight 375.5
CAS Number 934353-76-1, 1291074-87-7 (Tartrate)
SMILES CC1=CC(=NN1)NC2=NC(=NC(=C2)N3CCN(CC3)C)/C=C/C4=CC=CC=C4
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro (25°C) DMSO 101 mg/mL (268.99 mM)
Water 1 mg/mL (2.66 mM)
Ethanol Insoluble
In vivo 0.5% CMC+0.25% Tween 80 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.63 mL 133.16 mL 266.31 mL
0.5 mM 5.33 mL 26.63 mL 53.26 mL
1 mM 2.66 mL 13.32 mL 26.63 mL
5 mM 0.53 mL 2.66 mL 5.33 mL
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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