ENMD-2076

Catalog No.: A10352

Aurora A / FLT3 Inhibitor

ENMD-2076 Chemical Structure

CAS NO. 934353-76-1, 1291074-87-7

ENMD-2076 has selective activity against Aurora A and Flt3 with IC50 of 14 nM and 1.86 nM, 25-fold selective for Aurora A than over Aurora B and less potent to VEGFR2/KDR and VEGFR3, FGFR1 and FGFR2 and PDGFRα. Phase 2.

Availability: In stock

Package Price Qty
5 mg
$80.00
10 mg
$140.00
50 mg
$400.00
100 mg
$650.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

ENMD-2076 has selective activity against Aurora A and Flt3 with IC50 of 14 nM and 1.86 nM, 25-fold selective for Aurora A than over Aurora B and less potent to VEGFR2/KDR and VEGFR3, FGFR1 and FGFR2 and PDGFRα. Phase 2.
Targets
Target Value
FLT3IC50: 1.86nM
RETIC50: 10.4nM
AuroraAIC50: 14nM
VEGFR3/FLT4IC50: 15.9nM
SrcIC50: 20.2nM
NTRK1/TRKAIC50: 24.2nM
CSF-1R/c-FmsIC50: 24.8nM
LCKIC50: 43.7nM
FAKIC50: 54.9nM
PDGFRαIC50: 56.4nM
VEGFR2/KDRIC50: 58.2nM
BLKIC50: 69.4nM
FGFR2IC50: 70.8nM
YES1IC50: 78.4nM
Abl1(T315I)IC50: 81.3nM
FGFR1IC50: 92.7nM
FynIC50: 112nM
JAK2IC50: 120nM
KitIC50: 120nM
AuroraBIC50: 350nM
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.63 mL 133.16 mL 266.31 mL
0.5 mM 5.33 mL 26.63 mL 53.26 mL
1 mM 2.66 mL 13.32 mL 26.63 mL
5 mM 0.53 mL 2.66 mL 5.33 mL

*The above data is based on the productmolecular weight 375.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10352
Actions Inhibitor
M. Wt 375.5
Formula C21H25N7
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 934353-76-1, 1291074-87-7
Synonyms ENMD2076, ENMD 2076
SMILES CC1=CC(=NN1)NC2=NC(=NC(=C2)N3CCN(CC3)C)/C=C/C4=CC=CC=C4

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