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Publications citing Adooq Products
Chemical Information
| Catalog Num | A10352 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 375.5 |
| Formula | C21H25N7 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 934353-76-1, 1291074-87-7 |
| Synonyms | ENMD2076, ENMD 2076 |
| SMILES code | CC1=CC(=NN1)NC2=NC(=NC(=C2)N3CCN(CC3)C)/C=C/C4=CC=CC=C4 |
| Chemical Name | (E)-N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-1-yl)-2-styrylpyrimidin-4-amine |
Description |
ENMD-2076 has selective activity against Aurora A and Flt3 with IC50 of 14 nM and 1.86 nM, 25-fold selective for Aurora A than over Aurora B and less potent to VEGFR2/KDR and VEGFR3, FGFR1 and FGFR2 and PDGFRα. Phase 2. | ||||||||||||||||||||||||||||||||||||||||||
Targets |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 26.63 mL | 133.16 mL | 266.31mL |
| 0.5 mM | 5.33 mL | 26.63 mL | 53.26 mL |
| 1 mM | 2.66 mL | 13.32 mL | 26.63 mL |
| 5 mM | 0.53 mL | 2.66 mL | 5.33 mL |
*The above data is based on the productmolecular weight 375.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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