ENMD-2076

Catalog No.: A10352

Aurora A / FLT3 Inhibitor

ENMD-2076

ENMD-2076 Chemical Structure

CAS NO. 934353-76-1, 1291074-87-7

ENMD-2076 has selective activity against Aurora A and Flt3 with IC50 of 14 nM and 1.86 nM, 25-fold selective for Aurora A than over Aurora B and less potent to VEGFR2/KDR and VEGFR3, FGFR1 and FGFR2 and PDGFRα. Phase 2.

Availability: In stock

Package Price Qty
5 mg
$80.00
10 mg
$140.00
50 mg
$400.00
100 mg
$650.00
Custom Size Get quote

Free Overnight Delivery on orders over $500

Next day delivery by 10:00 a.m. Order now.

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

ENMD-2076 has selective activity against Aurora A and Flt3 with IC50 of 14 nM and 1.86 nM, 25-fold selective for Aurora A than over Aurora B and less potent to VEGFR2/KDR and VEGFR3, FGFR1 and FGFR2 and PDGFRα. Phase 2.
Targets
Target Value
FLT3IC50: 1.86nM
RETIC50: 10.4nM
AuroraAIC50: 14nM
VEGFR3/FLT4IC50: 15.9nM
SrcIC50: 20.2nM
NTRK1/TRKAIC50: 24.2nM
CSF-1R/c-FmsIC50: 24.8nM
LCKIC50: 43.7nM
FAKIC50: 54.9nM
PDGFRαIC50: 56.4nM
VEGFR2/KDRIC50: 58.2nM
BLKIC50: 69.4nM
FGFR2IC50: 70.8nM
YES1IC50: 78.4nM
Abl1(T315I)IC50: 81.3nM
FGFR1IC50: 92.7nM
FynIC50: 112nM
JAK2IC50: 120nM
KitIC50: 120nM
AuroraBIC50: 350nM
In vitro (25°C) DMSO 101 mg/mL (268.99 mM)
Water 1 mg/mL (2.66 mM)
Ethanol Insoluble
In vivo 0.5% CMC+0.25% Tween 80 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.63 mL 133.16 mL 266.31 mL
0.5 mM 5.33 mL 26.63 mL 53.26 mL
1 mM 2.66 mL 13.32 mL 26.63 mL
5 mM 0.53 mL 2.66 mL 5.33 mL

*The above data is based on the productmolecular weight 375.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10352
Actions Inhibitor
CAS No. 934353-76-1, 1291074-87-7
Formula C21H25N7
M. Wt 375.5
Purity >98%
Synonyms ENMD2076, ENMD 2076
SMILES CC1=CC(=NN1)NC2=NC(=NC(=C2)N3CCN(CC3)C)/C=C/C4=CC=CC=C4
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Tags

Product Tags

Use spaces to separate tags. Use single quotes (') for phrases.

Product Questions

Product Questions

No Questions
Keywords:buy ENMD-2076 | ENMD-2076 Supplier | purchase | cost | manufacturer | order | distributor | buy 934353-76-1, 1291074-87-7| 934353-76-1, 1291074-87-7 Supplier | purchase 934353-76-1, 1291074-87-7 | 934353-76-1, 1291074-87-7 cost | 934353-76-1, 1291074-87-7 manufacturer | order 934353-76-1, 1291074-87-7 | 934353-76-1, 1291074-87-7 distributor
Rewards