Fig. 1 · Structure
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Enpp-1-IN-20
ENPP1 Inhibitor
Enpp-1-IN-20 is a selective inhibitor of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1), exhibiting an IC50 of 0.09 nM. This compound demonstrates significant potency in cell-based assays, with an IC50 of 8.8 nM, effectively inhibiting ENPP1 activity while stimulating the STING pathway in vitro. Enpp-1-IN-20 is suitable for research applications in cancer biology, providing insights into ENPP1's role in tumorigenesis and immune response modulation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 3029600-37-8 |
| Applications | ENPP1 Inhibitor |
| Formula | C14H17N4O4P |
| Molecular Weight | 336.28 |
| SMILES | O=C1NC(N=CN=C2N3C[C@@]4([C@]([H])(C3)[C@H]4CCP(O)(O)=O)[H])=C2C=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.