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Enpp-1-IN-27

ENPP1 Inhibitor

Enpp-1-IN-27 is a potent and selective ENPP1 inhibitor, demonstrating an IC50 of 14.68 nM, along with significant selectivity against ENPP2 and ENPP3. This compound is instrumental in stabilizing cGAMP levels and activating the STING pathway, thereby promoting cytokine release and enhancing innate immune responses. Enpp-1-IN-27 effectively induces ISRE activation and amplifies cGAMP-mediated immune responses, exhibiting antitumor efficacy in 4T1 and CT26 syngeneic mouse models. It is a valuable reagent for research related to breast cancer and colon cancer.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	3105103-33-8
Applications	ENPP1 Inhibitor
Formula	C₁₃H₁₉ClN₆O₃S
Molecular Weight	374.85
SMILES	O=C1NC(N=CN=C2N3CCC(CNS(N)(=O)=O)(CC3)CCl)=C2C1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.