Enpp/Carbonic anhydrase-IN-2 is a potent inhibitor of ecto-nucleotide pyrophosphatase/phosphodiesterase (Enpp) and carbonic anhydrases, exhibiting IC50 values of 1.13 µM for NPP1, 1.07 µM for NPP2, 0.74 µM for NPP3, 0.33 µM for CA-IX, and 0.68 µM for CA-XII. This compound demonstrates significant antiproliferative effects on cancer cells while maintaining low cytotoxicity toward normal cell lines. Additionally, Enpp/Carbonic anhydrase-IN-2 has been shown to induce apoptosis, making it a valuable tool for cancer biology research and therapeutic development.
Enpp/Carbonic anhydrase-IN-2 is a potent inhibitor of ecto-nucleotide pyrophosphatase/phosphodiesterase (Enpp) and carbonic anhydrases, exhibiting IC50 values of 1.13 µM for NPP1, 1.07 µM for NPP2, 0.74 µM for NPP3, 0.33 µM for CA-IX, and 0.68 µM for CA-XII. This compound demonstrates significant antiproliferative effects on cancer cells while maintaining low cytotoxicity toward normal cell lines. Additionally, Enpp/Carbonic anhydrase-IN-2 has been shown to induce apoptosis, making it a valuable tool for cancer biology research and therapeutic development.
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