Fig. 1 · Structure
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ent-Ezetimibe
NPC1L1 Inhibitor
Ent-Ezetimibe is a potent inhibitor of the Niemann-Pick C1-like 1 (NPC1L1) protein, primarily known for its role in cholesterol absorption. As the RRS-enantiomer of Ezetimibe, it demonstrates significant biological activity in reducing intestinal cholesterol uptake. This compound is valuable in research focused on lipid metabolism and related cardiovascular studies. Additionally, ent-Ezetimibe serves as a potent Nrf2 activator, contributing to its utility in investigations surrounding oxidative stress and cellular defense mechanisms.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1376614-99-1 |
| Applications | NPC1L1 Inhibitor |
| Formula | C24H21F2NO3 |
| Molecular Weight | 409.43 |
| Synonyms | ent-SCH 58235 |
| SMILES | O=C1N(C2=CC=C(F)C=C2)[C@@H](C3=CC=C(O)C=C3)[C@@H]1CC[C@H](C4=CC=C(F)C=C4)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.