Fig. 1 · Structure
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Ent-(+)-Verticilide
Ryanodine-Binding Inhibitor
Ent-(+)-Verticilide is a potent and selective inhibitor of the cardiac ryanodine receptor (RyR2), which plays a critical role in calcium release channels. This compound demonstrates significant antiarrhythmic activity by effectively inhibiting RyR2-mediated diastolic Ca2+ leak. With its distinct mechanism of action, ent-(+)-verticilide serves as a valuable tool for exploring the therapeutic potential of targeting RyR2 hyperactivity in various heart and brain pathologies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2056011-05-1 |
| Applications | Ryanodine-Binding Inhibitor |
| Formula | C44H76N4O12 |
| Molecular Weight | 853.09 |
| SMILES | CCCCC[C@H]1C(N([C@@H](C(O[C@H](C(N([C@@H](C(O[C@H](C(N([C@@H](C(O[C@H](C(N([C@@H](C(O1)=O)C)C)=O)CCCCC)=O)C)C)=O)CCCCC)=O)C)C)=O)CCCCC)=O)C)C)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.