Fig. 1 · Structure
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EOS789
Sodium-dependent phosphate transporter inhibitor
EOS789 is a sodium-dependent phosphate transporter inhibitor that effectively reduces hyperphosphatemia and ameliorates kidney dysfunction. In preclinical studies using an anti-glomerular basement membrane nephritis rat model, EOS789 demonstrated a dose-dependent decline in serum creatinine levels, indicating potential therapeutic applications in managing phosphate levels and supporting kidney health. This reagent is valuable for researchers investigating renal pathologies and phosphate transport mechanisms.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1628848-73-6 |
| Applications | Sodium-dependent phosphate transporter inhibitor |
| Formula | C35H36F8N6O5 |
| Molecular Weight | 772.70 |
| SMILES | O=C(NC=1C=CC(=CC1C2=NC=NC(=C2)C(F)(F)F)C(F)(F)F)C=3C(=O)N(N(C)C4(C3O)CCCC4)CC5=CC=C(OCCN(C)CCOC)C(F)=C5F |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.