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Epacadostat is a potent and selective indoleamine 2,3-dioxygenase (IDO1) inhibitor with IC50 of 10 nM, Phase 2,
Targets
| IDO1 | ||||
| 10 nM |
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.82 mL | 114.1 mL | 228.19 mL |
| 0.5 mM | 4.56 mL | 22.82 mL | 45.64 mL |
| 1 mM | 2.28 mL | 11.41 mL | 22.82 mL |
| 5 mM | 0.46 mL | 2.28 mL | 4.56 mL |
*The above data is based on the productmolecular weight 438.23. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Technical Details
| Catalog Num | A15554 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 438.23 |
| Formula | C11H13BrFN7O4S |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 1204669-58-8, 1204669-37-3 |
| Synonyms | INCB 024360 |
| SMILES | C1=CC(=C(C=C1NC(=C2C(=NON2)NCCNS(=O)(=O)N)N=O)Br)F |
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