EPHA4 antagonist-1

Catalog No.: A84703
EphA4 Receptor Antagonist
EPHA4 antagonist-1 is a selective antagonist of the EphA4 receptor, known for its role in cell signaling, particularly in neuronal development and angiogenesis. This compound effectively inhibits ephrin-A5 binding to the EphA4 Fc receptor with an IC50 value of 10 μM, demonstrating its potency in disrupting EphA4-mediated signaling pathways. The compound's dual action as an EphA2 receptor antagonist expands its utility in biological research, making it valuable for studies on Eph receptor interactions and their implications in cancer and neurobiology.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
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Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
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Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
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Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionEPHA4 antagonist-1 is a selective antagonist of the EphA4 receptor, known for its role in cell signaling, particularly in neuronal development and angiogenesis. This compound effectively inhibits ephrin-A5 binding to the EphA4 Fc receptor with an IC50 value of 10 μM, demonstrating its potency in disrupting EphA4-mediated signaling pathways. The compound's dual action as an EphA2 receptor antagonist expands its utility in biological research, making it valuable for studies on Eph receptor interactions and their implications in cancer and neurobiology.
Product Information
Catalog NumA84703
FormulaC13H13NO3
Molecular Weight231.25
CAS Number313701-92-7
SMILESO=C(C1=CC(N2C(C)=CC=C2C)=CC=C1O)O
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