EPHA4 antagonist-1 is a selective antagonist of the EphA4 receptor, known for its role in cell signaling, particularly in neuronal development and angiogenesis. This compound effectively inhibits ephrin-A5 binding to the EphA4 Fc receptor with an IC50 value of 10 μM, demonstrating its potency in disrupting EphA4-mediated signaling pathways. The compound's dual action as an EphA2 receptor antagonist expands its utility in biological research, making it valuable for studies on Eph receptor interactions and their implications in cancer and neurobiology.
EPHA4 antagonist-1 is a selective antagonist of the EphA4 receptor, known for its role in cell signaling, particularly in neuronal development and angiogenesis. This compound effectively inhibits ephrin-A5 binding to the EphA4 Fc receptor with an IC50 value of 10 μM, demonstrating its potency in disrupting EphA4-mediated signaling pathways. The compound's dual action as an EphA2 receptor antagonist expands its utility in biological research, making it valuable for studies on Eph receptor interactions and their implications in cancer and neurobiology.
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