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EphB4-IN-1

EphB4 Inhibitor

EphB4-IN-1 is a selective inhibitor of the EphB4 tyrosine kinase, exhibiting IC50 values between 0.16 and 0.30 μM. By binding to the ATP binding site of EphB4 in a DFG-in conformation, it forms four stable intermolecular hydrogen bonds and effectively inhibits EphB4 autophosphorylation. Additionally, EphB4-IN-1 shows inhibitory activity against Src, Abl1, Lck, and EGFR kinases. This compound is valuable for research into cancers, including non-small cell lung cancer.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	1394837-94-5
Applications	EphB4 Inhibitor
Formula	C₁₈H₁₈N₄O₂
Molecular Weight	322.36
SMILES	O=C1C2=C(CCCC2)C3=C(N1C4=CC(O)=CC=C4C)N=CN=C3N

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.