Search by product name, CAS, target or catalog number. Press Down Arrow to reach product suggestions, Tab to move between links, and Escape to close suggestions.
Sirtuin inhibitors and activators target the seven mammalian sirtuins, a family of protein deacetylases. Yeast silent information regulator 2 (Sir2), the founding member, is a histone deacetylase that requires nicotinamide adenine dinucleotide (NAD+). Human sirtuins (SIRT1 to SIRT7) differ in location, with SIRT1 mainly nuclear, SIRT2 mainly cytoplasmic and SIRT3 to SIRT5 in mitochondria. Selisistat, also known as EX-527, inhibits SIRT1, and SirReal2 selectively inhibits SIRT2. SRT1720 HCl and SRT2104 are described as synthetic SIRT1 activators. Nicotinamide, a product of the sirtuin reaction, inhibits sirtuin activity, while nicotinamide riboside is a precursor of NAD+.
