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YT521-B homology domain family (YTHDF) proteins participate in recognition of methylated ribonucleic acid (RNA). The family is studied as part of post-transcriptional regulation, linking chemical marks on transcripts to their cellular handling. YTH-IN-1 is listed as an inhibitor across several YTH domain proteins, while YTHDF2 ligand-1 is assigned as a ligand of family member 2. The selection also contains compounds with broader biological annotations. These differences matter when distinguishing direct reader-protein ligands from compounds associated with related pathways.