Eptapirone (F-11440)

Catalog No.: A18338

5-HT1A receptor agonist

Eptapirone (F-11440)

Eptapirone (F-11440) Chemical Structure

CAS NO. 179756-58-2

Eptapirone is a potent, selective, high efficacy 5-HT1A receptor agonist with marked anxiolytic and antidepressant potential. The affinity of F 11440 for 5-HT1A binding sites (pKi, 8.33) was higher than that of buspirone (pKi, 7.50), and somewhat lower than that of flesinoxan (pKi, 8.91). In vivo, F 11440 was 4- to 20-fold more potent than flesinoxan, and 30- to 60-fold more potent than buspirone.

Availability: In stock

Package Price Qty
1 mg
$40.00
5 mg
$100.00
10 mg
$180.00
50 mg
$560.00
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Biological Activity

Eptapirone is a potent, selective, high efficacy 5-HT1A receptor agonist with marked anxiolytic and antidepressant potential. The affinity of F 11440 for 5-HT1A binding sites (pKi, 8.33) was higher than that of buspirone (pKi, 7.50), and somewhat lower than that of flesinoxan (pKi, 8.91). In vivo, F 11440 was 4- to 20-fold more potent than flesinoxan, and 30- to 60-fold more potent than buspirone.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 28.95 mL 144.76 mL 289.51 mL
0.5 mM 5.79 mL 28.95 mL 57.9 mL
1 mM 2.9 mL 14.48 mL 28.95 mL
5 mM 0.58 mL 2.9 mL 5.79 mL

*The above data is based on the productmolecular weight 345.407. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A18338
Actions Agonist
M. Wt 345.407
Formula C16H23N7O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 179756-58-2
Synonyms F11440, F 11440
SMILES O=C(N1C)N(CCCCN2CCN(C3=NC=CC=N3)CC2)N=CC1=O

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