Fig. 1 · Structure
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ER degrader 9
ER degrader
ER Degrader 9 is a potent bifunctional molecular glue that targets the estrogen receptor (ER) for degradation. Exhibiting a DC50 value of ≤10 nM in MCF-7 cells, this compound effectively induces ER degradation, making it a valuable tool for investigating breast cancer pathways and therapeutic responses. Its application in research may contribute to the development of innovative treatments for ER-positive breast cancer.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Degrader |
| CAS Number | 3023359-75-0 |
| Applications | ER degrader |
| Formula | C40H48N4O2 |
| Molecular Weight | 616.83 |
| SMILES | CC(C)(/C=C(C(N1CCN(CC1)CC2CCN(CC2)C3=CC=C(C=C3)[C@H]4[C@H](CCC5=CC(O)=CC=C54)C6=CC=CC=C6)=O)/C#N)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.