Fig. 1 · Structure
Documents & Downloads
Eragidomide
Cereblon Modulator
Eragidomide is a selective cereblon (CRBN) E3 ligase modulator that acts as a molecular glue, specifically targeting GSPT1 for ubiquitination. By co-opting the CRL4CRBN complex, Eragidomide facilitates the proteasomal degradation of GSPT1, leading to significant biological effects. This compound is primarily utilized in research applications focused on cancer biology and therapeutic strategies that exploit the proteasome pathway.
In Stock
Free Aliquoting for Your Order
Tell us your preferred amount per vial. We’ll confirm the options.
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 1860875-51-9 |
| Applications | Cereblon Modulator |
| Formula | C22H18ClF2N3O4 |
| Molecular Weight | 461.85 |
| Synonyms | CC-90009 |
| SMILES | O=C(NCC1=CC2=C(C(N(C(CC3)C(NC3=O)=O)C2)=O)C=C1)C(F)(F)C4=CC=C(Cl)C=C4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.