Fig. 1 · Structure
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ERCC1-XPF-IN-2
ERCC1-XPF Inhibitor
ERCC1-XPF-IN-2 is a potent inhibitor of the ERCC1-XPF endonuclease, demonstrating an IC50 value of 0.6 μM. This compound is significant in the study of nucleotide excision repair mechanisms, and it has been shown to enhance the efficacy of cisplatin treatments. Additionally, ERCC1-XPF-IN-2 is applicable in γH2AX assays, making it a valuable tool for research on DNA repair pathways and their implications in cancer therapy.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1808986-37-9 |
| Applications | ERCC1-XPF Inhibitor |
| Formula | C15H13Cl2NO3 |
| Molecular Weight | 326.17 |
| SMILES | OC1=C(O)C=C(CNC(CC2=C(Cl)C=C(Cl)C=C2)=O)C=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.