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ERG-IN-4

ERG Inhibitor

ERG-IN-4 is a selective ERG inhibitor that shows potent activity with an IC50 of 5.2 μM for the hERG channel. This compound activates the pregnane X receptor (PXR) and has demonstrated significant anticancer effects against MTAP-deleted non-small cell lung cancer. ERG-IN-4 presents a valuable tool for research in cancer therapy and pharmacological studies targeting ERG-related pathways.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	3047672-14-7
Applications	ERG Inhibitor
Formula	C₂₄H₂₂F₃N₇O₂
Molecular Weight	497.47
SMILES	CN(N=C1)C2=C1C(N)=NC3=C2C=C(C(N(N(C(C4CC4)=O)C)CC5=NC=C(C(F)(F)F)C=C5)=O)C=C3

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.