Fig. 1 · Structure
Documents & Downloads
Erlotinib-13C6
13C-Labeled Erlotinib
Erlotinib-13C6 is a 13C-labeled form of Erlotinib, which specifically targets the epidermal growth factor receptor (EGFR) by acting as a potent tyrosine kinase inhibitor. It demonstrates an IC50 of 2 nM for human EGFR, facilitating its application in research focused on cancer therapeutics and signaling pathways. This isotopically enriched compound is valuable for metabolic studies and pharmacokinetic investigations involving EGFR-targeted therapies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1211107-68-4 |
| Applications | 13C-Labeled Erlotinib |
| Formula | C1613C6H23N3O4 |
| Molecular Weight | 399.39 |
| Synonyms | CP-358774-13C6; NSC 718781-13C6; OSI-774-13C6 |
| SMILES | COCCOC(C(OCCOC)=C1)=CC2=C1C(N[13C]3=[13CH][13C](C#C)=[13CH][13CH]=[13CH]3)=NC=N2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.