Fig. 1 · Structure
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Etamicastat hydrochloride
DBH Inhibitor
Etamicastat hydrochloride is a potent and reversible inhibitor of dopamine-β-hydroxylase (DBH), exhibiting an IC50 value of 107 nM. This compound is valuable for research focused on cardiovascular diseases, where modulation of catecholamine levels can influence disease pathology and treatment outcomes. Its specificity and effectiveness make it a useful tool for exploring DBH-related mechanisms in various cardiovascular conditions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 677773-32-9 |
| Applications | DBH Inhibitor |
| Formula | C14H16ClF2N3OS |
| Molecular Weight | 347.81 |
| Synonyms | BIA 5-453 hydrochloride |
| SMILES | FC1=CC(F)=C2OC[C@@H](CC2=C1)N3C(CCN)=CNC3=S.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.