Fig. 1 · Structure
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ETC-168
MNK Inhibitor
ETC-168 is a selective oral active inhibitor of MNK (MAP kinase-interacting serine/threonine-protein kinase) with IC50 values of 23 nM for MNK1 and 43 nM for MNK2. This compound demonstrates significant antiproliferative activity in both in vivo and in vitro models, making it a valuable tool for research into cancer biology and therapeutic development targeting MNK pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1464150-99-9 |
| Applications | MNK Inhibitor |
| Formula | C24H19N5O2 |
| Molecular Weight | 409.44 |
| SMILES | N#CC1=CC=C(C2=CN=C3C=CC(C4=CC=C(C(N5CCOCC5)=O)C=C4)=NN32)C=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.