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Fig. 1 · Structure
Cat. No.
A19366
CAS No.
1464151-33-4
Formula
C25H20N4O2
Mol. Weight
408.45

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Tinodasertib (ETC-206)

Cat. No. A19366 CAS 1464151-33-4

MNK1 and MNK2 inhibitor

ETC-206 is a selective MNK1 and MNK2 inhibitor with IC50s of 64 nM and 86 nM, respectively.

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Biological Activity

Target & Activity

Target Activity Value
MNK1 IC50 64 nM
MNK2 IC50 86 nM

Cellular Effect

Cell Line Activity Value Description Reference
DOHH-2 IC50 1.624 μM Antiproliferative activity against human DOHH-2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay [PMID: 33971490]
HEK293 IC50 64 nM Inhibition of MNK1 (unknown origin) expressed in HEK293 cells assessed as decrease in eIF4E phosphorylation at Ser209 residues by Western blot analysis [PMID: 30530193]
HEK293 IC50 86 nM Inhibition of MNK2 (unknown origin) expressed in HEK293 cells assessed as decrease in eIF4E phosphorylation at Ser209 residues by Western blot analysis [PMID: 30530193]
TMD8 IC50 2.138 μM Antiproliferative activity against human TMD8 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay [PMID: 33971490]

Specifications

Manufacturer Adooq Bioscience
Actions Inhibitor
CAS Number 1464151-33-4
Applications MNK1 and MNK2 inhibitor
Formula C25H20N4O2
Molecular Weight 408.45
Synonyms ETC 206
SMILES
N#CC1=CC=C(C2=CN=C3C=CC(C4=CC=C(C(N5CCOCC5)=O)C=C4)=CN32)C=C1

Storage & Solubility

In Vitro Solubility

Reported Solubility

SolventReported Solubility
DMSO 79 mg/mL (193.41 mM)
Water Insoluble
Ethanol Insoluble

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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