Fig. 1 · Structure
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Etelcalcetide
CaSR Activator
Etelcalcetide is a synthetic calcimimetic that acts as an activator of the calcium sensing receptor (CaSR). This compound effectively reduces parathyroid hormone (PTH) levels, making it a valuable tool for research in secondary hyperparathyroidism, particularly in patients undergoing hemodialysis. Its role in modulating calcium homeostasis holds potential for studying chronic kidney disease and related disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Activator |
| CAS Number | 1262780-97-1 |
| Applications | CaSR Activator |
| Formula | C38H73N21O10S2 |
| Molecular Weight | 1048.25 |
| Synonyms | Velcalcetide; AMG 416; KAI-4169 |
| SMILES | C[C@@H](NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](C)NC(=O)[C@@H](CSSC[C@H](N)C(O)=O)NC(C)=O)C(=O)N[C@H](CCCNC(N)=N)C(N)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.